Japanese medicine may help grow new teeth in humans


Some sharks shed new teeth as often as once a week. This is while crocodiles get new teeth thousands of times during their long life. Despite this, the ability to endlessly replace teeth is something that we and other mammals lack. The 32 permanent teeth that grow into adulthood are all we get in our lifetime.

But according to the report New AtlasNow, a team of Japanese scientists is going to test a drug that helps grow new teeth in humans.

According to the plan, the clinical trial of the new drug will be conducted in June 2024. This trial is first conducted on participants who have edentulous disease (a genetic disease of not having teeth); Of course, scientists plan to make this treatment available to the public by 2030.

“The idea of ​​a new tooth growing in is every dentist’s dream,” says Katsu Takahashi, senior researcher and head of the Department of Dentistry and Oral Surgery at Kitano Medical Research Institute Hospital in Osaka. “I’ve been working on this since I was a graduate student and I was confident that I could make it happen one day.”

Previously, researchers in a study focused on an antibody belonging to the gene associated with uterine sensitivity 1 (USAG-1). This antibody can stimulate the growth of new teeth in edentulous mice.

The scientists found that USAG-1 interacts with other proteins in the body to suppress tooth growth. Blocking this interaction can help bone morphogenic protein signaling and ultimately lead to the growth of new teeth.

After the trial on mice in 2018, other trials on domestic minks have had similar success in growing new teeth. The animals developed a seventh front tooth that was similar in shape and structure to the adjacent specimens. “We hope to pave the way for clinical use of the drug,” says Takahashi.

For years, scientists have been trying to decipher the genetic expression code that allows animals like sharks to continuously grow teeth; But its practical application for humans has been unattainable so far.

The preliminary study of researchers in 2021 Science Indonesia magazine Released.


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